Purdue Pharma is developing a long-acting opioid antagonist for treating overdoses that will likely be of interest to the workers’ compensation community, pharmacy benefit manager myMatrixx reports.
The drug under development, nalmefene, has a plasma half-life of almost 11 hours, myMatrixx said. The only FDA-approved treatment for opioid overdose, naloxone, has a half-life of about two hours.
“As a result, nalmefene has been shown to reverse opioid intoxication for as long as eight hours, whereas naloxone requires monitoring and repeat dosing, as needed,” myMatrixx said.
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